Toxic Epidermal Necrolysis Induced by Carbamazepine: A Case Report

Background: Toxic epidermal necrolysis (TEN) is an uncommon but potentially fatal condition. TEN distinguished by apoptosis of keratinocytes, which results in erosion the mucous membrane and detachment. Case: A man, 20-year-old, came to hospital with skin sore blisters almost over his body, accompanied swollen eyes, on lips genital. Dermatological examination regio trunk showed erythematous hyperpigmented macules, irregularly shaped, multiple flaccid bullae, The suspected drug, carbamazepine was discontinued immediately, then patient given appropriate supportive treatment intravenous fluid drop (IVFD), systemic corticosteroid, antibiotic, topical treatment. After 10 days, recovery reepithelialization mucosal stabilized. discharged after 12 days if admission. Drug patch testing performed resulting positive result for carbamazepine. Conclusion: accurate diagnosis, avoidance use causative drug rapid may improve prognosis. reactions have high predictive value avoid using that future.